Ultimate 12-Day Peru Itinerary: From Machu Picchu to the Amazon

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Advisor - Ana Santos
Curated By

Ana Santos

  • Active Travel

  • Adventure Travel

  • Arts & Culture

  • Couples Travel

  • Peru

  • Local Culture

  • Local Food

  • Sightseeing

Majestic mountains and clouds surround the ancient Incan city of Machu Picchu.
Curator’s statement

Peru is a land of unforgettable contrasts—where ancient ruins meet vibrant culture, and breathtaking landscapes stretch from the Amazon to the Andes. Whether you're dreaming of exploring Machu Picchu, venturing into the Amazon rainforest or strolling the lively streets of Cusco, this guide will give you a taste of what makes Peru so special.

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Day 1: Arrive in Lima, Peru’s vibrant capital

An aerial view of a cityscape during sunset, with buildings, roads and mountains under a partly cloudy sky.

Before diving into your adventure, take some time to explore the city’s fascinating blend of ancient history and modern culture. Visit the Larco Museum for a glimpse into Peru’s rich past, and don’t miss the chance to indulge in Lima’s incredible food scene—it’s a true culinary hotspot. If you arrive early, consider a walking tour to get a feel for the city before heading to your hotel.

Days 2-4: Immerse yourself in the Amazon

A leopard rests on a tree branch amidst dense green foliage.

Your journey into the heart of the Amazon begins with a flight to Puerto Maldonado, followed by a scenic ride to your eco-lodge. Over the next few days, you’ll dive into the wonders of the rainforest—exploring winding rivers, lush jungle trails and spotting unique wildlife. Whether it’s a guided nature walk, a boat ride or simply relaxing at your lodge, these days offer a chance to connect with nature in one of the world’s most untouched landscapes.

Day 5: Journey to the Sacred Valley

An archaeological site with large stone structures in the foreground and a densely built hillside city in the background.

Today, you’ll leave the rainforest behind and head into the majestic Sacred Valley. On the way, stop by the incredible Sacsayhuaman ruins, an awe-inspiring Inca structure with breathtaking views. The Sacred Valley is the perfect spot to acclimate to the altitude before exploring Cusco. Spend the afternoon settling into this peaceful region, surrounded by stunning mountain landscapes and rich history.

Days 6-8: Explore Sacred Valley, Aguas Calientes & Machu Picchu

A person looks out over the ancient Incan city of Machu Picchu amidst a mountainous landscape under a partly cloudy sky.

Spend time exploring the Sacred Valley—from the artisan markets of Chinchero to the salt pools of Maras and the fascinating terraces of Moray. Don’t miss the ancient Inca fortress at Ollantaytambo before boarding the breathtaking Vistadome train to Aguas Calientes. The highlight of your journey comes the next morning with a visit to Machu Picchu. Beat the crowds with an early start and take in the magical views of this iconic site, nestled high in the Andes. If you’re feeling adventurous, consider adding the Huayna Picchu hike for an even more spectacular view.

Day 9: Discover the vibrant city of Cusco

An aerial view of a densely packed urban area with numerous buildings and a prominent central square with a large church.

Today, you’ll explore the vibrant city of Cusco, once the heart of the Inca Empire. Wander through the lively Plaza de Armas, visit the remains of Coricancha, the ancient temple of the sun, and stroll down historic streets lined with historic architecture and Inca stonework. Don’t miss the San Blas neighborhood, known for its artsy vibe, or the bustling San Pedro Market for a taste of local culture.

Days 10-11: Visit Lake Titicaca & the Floating Islands

A tranquil body of water with a clear blue sky, tall grasses and a hill in the background.

Fly from Cusco to Puno, your gateway to the stunning Lake Titicaca. On the way, visit the Chullpas de Sillustani, ancient funerary towers that stand as a testament to Peru’s pre-Inca history. Once at Lake Titicaca, explore the famous Uros Islands, floating islands made entirely of reeds, and learn about the unique culture of the islanders. Then, visit Taquile Island, known for its incredible textiles and breathtaking views of the lake. Whether by boat or on foot, these days are about experiencing the beauty and traditions of one of Peru’s most fascinating regions.

Day 12: Return to Lima & fly home

The image shows an airplane's wingtip against a clear sky, sandy ground and airport infrastructure.

Your adventure in Peru comes to an end as you take a flight back to Lima. If time allows, enjoy a final meal in the city or explore a bit more before heading to the airport for your flight home. Whether you’ve immersed yourself in Peru’s ancient ruins, vibrant cities or stunning landscapes, this journey will leave you with unforgettable memories and plenty of stories to tell.

Need to know

When to visit Peru: The best time to visit Peru depends on what you want to experience. If you’re into hiking, the dry season from May to October is perfect for clear skies and trekking in the Andes. For visiting Machu Picchu with fewer crowds, aim for the shoulder seasons, April and May or September and October. If you’re exploring the Amazon, the wet season, from November to April, brings lush landscapes and abundant wildlife. No matter when you go, Peru’s diverse climate means you can find something amazing year-round.

Advisor - Ana Santos

Travel Advisor

Ana Santos

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This itinerary is a part of our ongoing series on travel to Peru. Looking for more travel inspiration? Check out my guide, Utah Adventure Guide: 7-Day Itinerary.